脂肪细胞因子与代谢综合征的相关性研究

Correlation between adipocyte factors and metabolic syndrome

目的研究脂肪细胞因子、炎性因子和代谢综合征(MS)的相互关系,进一步探索MS发生的危险性。方法采用免疫组化法检测性激素结合蛋白(SHBG)、瘦素(leptin)、脂联素(adiponectin)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)和MS的关系,了解MS患者和正常人的临床测量及一般代谢指标的变化;进行单因素和多因素Logistic回归分析,观察上述细胞因子对MS的影响。结果不论男女,MS组SHBG、adiponectin细胞因子低于正常组,TNF-α、IL-6细胞因子高于正常组(P<0.05)。MS组男女CRP和男性的leptin与正常组比较差异无统计学意义。甘油三酯、总胆固醇、餐后2 h血糖、空腹胰岛素、腰臀比及细胞因子IL-6、leptin是MS组的危险因素,而SHBG、高密度脂蛋白—胆固醇是MS的保护因素。结论脂肪细胞因子adiponectin、leptin、SHBG和MS有紧密的联系。

Objective To study the correlation among adipocyte factors, inflammatory factors and metabolic syndrome （MS） , and to identify the occurrence possibilities of MS. Methods The immunohistochemical method was used to detect the correlations between MS phenotype and sex hormone-binding globulin （SHBG）, leptin, adiponeetin, c-reactive protein （CRP）, tumor necrosis factor alpha （TNF-α）, interleukin-6 （IL-6）. To observe the changes of metabolic indicators and clinical tests between MS patients and normal persons. To conduct univariate and multivariate logistic regression analysis and to find out the influence on MS produced by cell factors listed above. Results Both male and female, the contents of SHBG and adiponectin in MS group were lower than those in the normal group, but the contents of TNF-α and IL-6 in MS Group were higher than those in the normal group, and the differences were significant （ P 〈 0.05 ）. Compare MS group and the normal group, the differences concerning CRP （both male and female） and leptin （male） did not demonstrate statistical significance. Triglyceride, cholesterol, postprandial 2 h blood glucose, fasting insulin, waist-hip ratio, IL-6 and leptin were the risk factors causing MS, while SHBG and high density lipoprotein cholesterol were protective factors of MS. Conclusion The adipocyte factors of adiponeetin, leptin and SHBG are highly correlated with MS.