期刊文献+

难治性癫癎靶点学说研究进展

下载PDF
导出
摘要 癫痫发病机制的研究在近30年内取得了极大的进展,尤其是在生理学和遗传学方面。1978年起,10种新型抗癫痫药物(antiepilepticdrugs,AED):丙戊酸、托吡酯、拉莫三嗪、加巴喷丁、非氨酯、奥卡西平、氨己烯酸、唑尼沙胺、左乙拉西坦和普瑞巴林等在临床的应用,极大地改善了癫痫的治疗。
出处 《癫痫与神经电生理学杂志》 2012年第6期374-377,共4页 Journal of Epileptology and Electroneurophysiology(China)
  • 相关文献

参考文献31

  • 1Rogawski MA, L6scher W. The neurobiology of antiepileptic drugs[J]. Nat Rev Neurosci,2004,5 :553- 564.
  • 2Maljevic S,Krarnpfl K,Cobilanschi J,et al. A mutation in the GABAA receptor al-subunit is associated with absence epilep-sy[J]. Ann Neurol, 2006, 59 : 983-987.
  • 3Hirose S, Mitsudome A, Okada M, et al. Genetics of idiopathic epilepsies[J]. Epilepsia,2005,46(Suppl 1) :38- 43.
  • 4Isom LL . The role of sodium channels in cell adhesion[J]. Front Biosci, 2002,7 : 12-23.
  • 5Kahlig KM, Misra SN ,George AL. Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy associated SCN]A mutation[J]. J Neurosei, 2006, 26: 10958-10966.
  • 6Khaliq ZM, Raman IM. Relative contributions of axonal and somatic Na channels to action potential initiation in cerebellar Purkinje neurons[J]. J Neurosci,2006, 26 : 1935-1944.
  • 7Escayg A, MacDonald BT, Meisler MH, et al. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+ 2 [J]. Nat Genet, 2000, 2 : 343-:345.
  • 8Claes L,Ceulemans B,Audenaert D,et al. De novoSCNiA mutations are a major cause ofsevere myoclonie epilepsy of infancy [J]. Hum Mutat,2001,21:615-621.
  • 9Fukuma G, Oguni H, Shirasaka Y, et ai. Mutations of neuronai voltage gated Na(+) channel al subunit gene SCN1A in core severe myoclonic epilepsy in infancy (SMEI) and in borderline SMEI (SMEB) [J]. Epilepsia, 2004,45 : 140-148.
  • 10Ellerkmann RK, Remy S, Chen J, et al, Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells[J]. Neuroscience, 2003,119,323-333.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部