摘要
以3-氨基-5-(2,3-二乙酰氧基正丙胺基甲酰基)-2,4,6-三碘苯甲酸为原料,依次经氨基酰化、酰氯化、胺解和酯水解等4步反应得到标题化合物,结构经1HNMR和MS确证,其纯度≥98%(HPLC归一化法)。标题化合物理化性质优于碘海醇,值得进一步评价。
N-Methyl-N-( 2-hydroxyethyl )-N′-( 2, 3-di- hydroxypropyl ) -5- ( 2-hydroxyaeetamido ) -2,4,6 -triiodoisoph- thalamide( STL-05 ) was synthesized from 3-amino-5-( 2,3-di- acetoxypropylcarbamoyl)-2,4,6-triiodobenzoic acid via ami- no-acylation, acyl chlorination, acylamination and esterolysis. STL-05(purity ≥98% ) was confirmed by 1^HNMR and MS. STL-05 has better physicochemical properties than iohexol and is worth further investigating.
出处
《化学试剂》
CAS
CSCD
北大核心
2012年第12期1108-1110,共3页
Chemical Reagents
关键词
碘造影剂
非离子型单体
合成
iodinated contrast agents
non-ionic monomer
synthesis