苗药双肾草中一个新的联苄类化合物

New Bibenzyl Derivative from Miao Medicine Herminium bulleyi

从苗药双肾草[Herminium bulleyi(Rolfe)Tang et Wang]块茎的甲醇提取物中分离鉴定了6个化合物,其中化合物6是新化合物,命名为双肾草素,经NMR等波谱解析,确定其结构为2,2-dimethyl-5-methoxy-7-[2-(3″-hydroxyphenyl)ethyl]chromene,其余化合物均为首次从该植物中分离得到.

Herminium bulleyi（Rolfe） Tang et Wang is a medicinal herb used to treat common disease such as impotent, premature ejaculation and spematorrhea by Miao in China. Despite of the widespread medicinal uses in Miao area, there is no phytochemical research on it. We had investigated its chemical consitituents for further sustainable utilization. In this work, six compounds were isolated and purification by silica gel, Sephadex LH-20 and RP-C18 gel column chromatography from methyl alcohol extract of the tubers of Herminium bulleyi. Their structures were elucidated on the basis of spectroscopic evidence, particularly by two-dimensional NMR spectroscopic analysis. And they were identified as palmitic acid（1）, 9,19-cyclo-9β-lanost-24-en-3-ol（2）, β-sitosterol （3）, glycerol monopalmitate （4）, monostearin （ 5 ） and shuangshencaosu 2,2-dimethyl-5-methoxy- 7- [ 2- （3＂-hydroxyphenyl） ethyl ] chromene （6）. Among them, compound 6 is a new compound, the others are firstly isolated from this species.