摘要
目的:探讨短时受精失败后行早补救ICSI的应用价值。方法:对2010年10月~2011年6月在唐山市妇幼保健院生殖遗传科接受IVF-ET治疗的28例患者(观察组)进行短时受精观察,于受精后4~6 h去除卵丘细胞,观察卵子的第二极体的排出情况,对第二极体排出率低于1/2的周期实施早期补救ICSI(观察组)。选择同期行ICSI治疗的63例患者作为对照组,比较两组的受精及妊娠情况。结果:观察组受精率高于对照组,差异有统计学意义(P<0.05),但多精受精率、优胚率、妊娠率无统计学意义(P>0.05)。结论:短时受精后行早补救ICSI能极大地提高卵母细胞的利用率,并获得很好的临床妊娠结局,对预防及降低受精失败有重要意义。
Objective: To explore the application value of early rescue intracytoplasmic sperm injection (ICSI) after short - period fertilization failure. Methods : Twenty - eight patients ( observation group) who received in vitro fertilization and embryo transfer ( IVF - ET) in genetic department of the hospital from October 2010 to June 2011 were treated with short -period fertilization, then cumulus cells were removed after 4 -6 hours, discharge of second polar body of oocytes was observed, early rescue ICSI was performed during the cycles with discharge rate of second polar body less than one half (observation group) . Sixty -three patients who received ICSI during the same period were selected as control group, the fertilization rates and pregnancy rates in the two groups were compared. Results: The fertilization rate in observation group was statistically significantly higher than that in control group (P 〈 O. 05 ), but there was no statistically significant differ- ence in polyspermy rate, high quality embryo rate, and pregnancy rate between the two groups (P 〉 O. 05) . Conclusion : Early rescue ICSI after short - period fertilization failure can improve the utilization rate of oocytes significantly and obtain good clinical pregnancy outcome, which has important significance for preventing and reducing fertilization failure.
出处
《中国妇幼保健》
CAS
北大核心
2012年第35期5751-5753,共3页
Maternal and Child Health Care of China
关键词
体外受精
受精失败
短时受精
第二极体
早补救ICSI
In vitro fertilization
Fertilization failure
Short -period fertilization
Second polar body
Early rescue intracytoplas- mic sperm injection