期刊文献+

短时受精失败后行早补救ICSI的临床应用研究 被引量:2

Clinical application and research on early rescue ICSI after short-period fertilization failure
原文传递
导出
摘要 目的:探讨短时受精失败后行早补救ICSI的应用价值。方法:对2010年10月~2011年6月在唐山市妇幼保健院生殖遗传科接受IVF-ET治疗的28例患者(观察组)进行短时受精观察,于受精后4~6 h去除卵丘细胞,观察卵子的第二极体的排出情况,对第二极体排出率低于1/2的周期实施早期补救ICSI(观察组)。选择同期行ICSI治疗的63例患者作为对照组,比较两组的受精及妊娠情况。结果:观察组受精率高于对照组,差异有统计学意义(P<0.05),但多精受精率、优胚率、妊娠率无统计学意义(P>0.05)。结论:短时受精后行早补救ICSI能极大地提高卵母细胞的利用率,并获得很好的临床妊娠结局,对预防及降低受精失败有重要意义。 Objective: To explore the application value of early rescue intracytoplasmic sperm injection (ICSI) after short - period fertilization failure. Methods : Twenty - eight patients ( observation group) who received in vitro fertilization and embryo transfer ( IVF - ET) in genetic department of the hospital from October 2010 to June 2011 were treated with short -period fertilization, then cumulus cells were removed after 4 -6 hours, discharge of second polar body of oocytes was observed, early rescue ICSI was performed during the cycles with discharge rate of second polar body less than one half (observation group) . Sixty -three patients who received ICSI during the same period were selected as control group, the fertilization rates and pregnancy rates in the two groups were compared. Results: The fertilization rate in observation group was statistically significantly higher than that in control group (P 〈 O. 05 ), but there was no statistically significant differ- ence in polyspermy rate, high quality embryo rate, and pregnancy rate between the two groups (P 〉 O. 05) . Conclusion : Early rescue ICSI after short - period fertilization failure can improve the utilization rate of oocytes significantly and obtain good clinical pregnancy outcome, which has important significance for preventing and reducing fertilization failure.
出处 《中国妇幼保健》 CAS 北大核心 2012年第35期5751-5753,共3页 Maternal and Child Health Care of China
关键词 体外受精 受精失败 短时受精 第二极体 早补救ICSI In vitro fertilization Fertilization failure Short -period fertilization Second polar body Early rescue intracytoplas- mic sperm injection
  • 相关文献

参考文献5

二级参考文献25

  • 1张凤英,张美姿,张云山,高企贤,王小茹,李媛.常规IVF授精后20-22h ICSI再授精的预后[J].第四军医大学学报,2005,26(7):667-669. 被引量:11
  • 2罗海宁,朱桂金,胡娟,王雁林,魏玉.体外受精失败MII期人卵母细胞的免疫荧光研究[J].生殖医学杂志,2005,14(2):75-77. 被引量:15
  • 3张丽红,李娟,江平,王克华,张琦,董云玲,张梅心,刘锦云,胥玉梅.常规体外受精失败患者卵浆内单精子注射治疗的结果分析[J].现代妇产科进展,2005,14(3):255-256. 被引量:5
  • 4徐艳文,周灿权,方丛,张敏芳,邓明芬,张秀冰.卵细胞胞质内单精子注射在前次常规体外受精失败病例中的应用[J].中华男科学杂志,2006,12(6):531-533. 被引量:11
  • 5AMARIN Z O,OBEIDAT B R,ROUZI A A,et al.Intracytoplasmic sperm injection after total conventional in-vitro fertilization failure[J].Saudi Med J,2005,26 (3):411-5.
  • 6CHEN C,KATTERA S.Rescue ICSI of oocytes that failed to extrude the second polar body 6 h postinsemination in conventional IVF[J].Hum Reprod,2003,18(10):2122-2123.
  • 7KABLY A A,BAPTISTA P-A A,RUIZ A J,et al.Unexpected failed fertilization in vitro:ICSI reinsemination or ICSI indication for subsequent cycles[J].Ginecol Obstet Mex,2002,70:373-378.
  • 8KUCZYNSKI W,DHONT M,GRYGORUK C,et al.Rescue ICSI of unfertilized oocytes after IVF[J].Hum Reprod,2002,17(9):2423-2427.
  • 9YUZPE AA,LIU Z,FLUKER M R.Rescue intracytoplasmic sperm injection (ICSI)-salvaging in vitro fertilization (IVF) cycles after total or near-total fertilization failure[J].Fertil Steril,2000,73(6):1115-1119.
  • 10MORTON P C,YODER C S,TUCKER M J,et al.Reinsemination by intracytoplasmic sperm injection of 1-day-old oocytes after complete conventional fertilization failure[J].Fertil Steril,1997,68(3):488-491.

共引文献40

同被引文献37

引证文献2

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部