三阴性乳腺癌临床病理特点及与ki67表达关系的分析

Analysis on the relationship between clinicopathological characteristics of triple-negative breast cancer and ki67 expression

目的:探讨三阴性乳腺癌的临床病理特点和预后特点以及ki67的表达情况与预后的关系。方法:选取浸润性乳腺癌患者271例,对其临床病理资料进行回顾性分析,统计随访结果和病理特征,并检测ki67的表达。结果:三阴性乳腺癌与非三阴性乳腺癌患者在绝经状态和肿瘤临床分期、淋巴结转移中ki67的表达存在差异且具有统计学意义(P<0.05)。相对于非三阴性患者,三阴性乳腺癌患者的生存率较低,差异有统计学意义(P<0.05)。ki67阳性的三阴性乳腺癌患者易出现淋巴结转移。结论:三阴性乳腺癌中Ki67阳性可作为患者不良预后的重要指标,对于指导临床治疗方案的制订具有重要意义。

Objective： To explore the relationship between clinicopathologieal and prognostic characteristics of triple -negative breast cancer （TNBC） and ki67 expression and prognosis. Methods： A total of 271 patients with invasive breast cancer were selected, then their clinicopathological data were analyzed retrospectively, the follow - up results and pathological characteristics were analyzed statistically, and the expression of ki67 were detected. Results： There were statistically significant differences in menopausal state, clinical stages, lymph node metastasis, and ki67 expression between patients with TNBC and patients without TNBC （ P 〈 0. 05 ） . The survival rate of patients with TNBC were statistically significantly lower than that of patients without TNBC （ P 〈 O. 05 ） . Lymph node metastasis occurred easily in TNBC patients with positive ki67. Conclusion： Positive Ki67 in TNBC patients can be used as an important index to indicate adverse prognosis, which has important significance for guiding drafting clinical therapeutic scheme.