亚甲蓝联合高压氧治疗急性亚硝酸盐中毒的临床疗效分析

The clinical analysis of methylene blue and hyperbaric oxygen on acute poisoning by nitrite

目的观察亚甲蓝联合高压氧对急性亚硝酸盐中毒的治疗效果。方法32例患者应用亚甲蓝联合高压氧进行治疗，观察治疗前后血气分析高铁血红蛋白（MetHb）量的变化。结果本组患者全部治愈，MetHb量在治疗前后比较差异有统计学意义（P〈0．001）。结论亚甲蓝联合高压氧对急性亚硝酸盐中毒治疗时间短，疗效佳，强调早期应用。

Objective To observe the treatment of methylene blue and hyperbaric oxygen on acute poisoning by nitrite. Methods 32 patients were treated by methylene blue and hyperbaric oxygen. The amount changes were observed about metbemoglobin （MetHb） in blood gas analysis before and after treatment. Results This group of patients were all cured and there were significant differences in the amount of MetHb before and after treatment （ P 〈 0. 001 ）. Conclusion Methylene blue and hyperbaric oxygen on acute poisoning by nitrite could shorten the time of treatment and it had excellent curative effect. It was worth being widely applied in early stage.