有氧运动对颈动脉顺应性与脉压放大的急性影响

Acute Effects of Aerobic Exercise on Carotid Artery Compliance and Pulse Pressure Amplification

目的:研究有氧运动对青年男性和女性颈动脉AC的急性影响,另一目的是研究急性有氧运动后PPA与颈动脉AC的关系。方法:对62名(男32,女30)受试者(年龄26±5岁)进行两次测试:第一次测试采用Bruce跑台模型,测取最大心率(HRmax)和峰值摄氧量(O2peak);间隔48h到2周进行第二次测试,主要测取安静状态、运动后30min和运动后60min的颈动脉以及肱动脉的相关指标。急性有氧运动为45min70%心率储备的跑台运动[目标心率=(最大心率-安静心率)×70%+安静心率]。结果:2×3ANOVA重复测量方差分析,两个性别在3时间点的颈动脉AC的变化存在显著性差异(P<0.05),β-stiffness不存在显著性差异。Person相关性分析(CI=95%),颈动脉AC和PPA呈显著正相关(r=0.653,P=0.00)。结论:有氧运动引起颈动脉AC的急性变化存在性别差异,可能是由于H2受体介导的血管舒张功能受性激素的影响引起。有氧运动后颈动脉AC的增大(或降低)可能是引起PPA增大(或降低)的重要因素。

Objectives：The purpose of this study was to determine the acute effects of aerobic exercise on carotid arterial compliance （AC） in men and women. An additional purpose of this study was to determine the association between change in carotid AC and change in pulse pressure amplification （PPA） following a bout of acute aerobic exercise. Methods. Sixty-two healthy individuals （age 26± 5 yrs;32 male and 30 female） underwent measurements of HR-max and VO2 peak by Bruce model in the first test;and then underwent measurements of some variable of carotid and brachial at rest, 30 minutes post and 60 minutes post a bout of acute exercise in 48 hours to 2 weeks after the first test. The acute exercise is a bout of 70% heart rate reserve aerobic exercise by treadmill continued 45 minutes. （target HR= （HRmax-HR at rest） X70%＋ HR at rest） Results： The change of carotid AC was difference （P〈0.05） analyzed by 2）〈 3 （2 genders ）〈 3 time points） repeated measures ANOVA; There was no change in the change of β-stiffness analyzed by 2 Х 3 repeated measures ANOVA. There was a significant positive correlation （r= 0.653 , P = 0.00） by person correlation analysis. Conclusion：The acute change of carotid AC was different between men and women following a bout of aerobic exercise. These different changes may be caused by sex hormones which influence vasodilatation mediated by H2 receptor. The increase （or decrease） of carotid AC may be an important factor to cause PPA to increase （or decrease） following a bout of aerobic exercise.