摘要
3-乙酰基-5-溴-卓酚酮与不同取代的苯甲醛类化合物通过Claisen-Schmidt缩合反应合成一系列结构新颖的卓酚酮取代的查尔酮类衍生物。该方法使用5%KOH溶液作为催化剂,50%甲醇水溶液作为溶剂,具有操作简便、反应条件温和、收率高等优点。所合成标题化合物的结构经IR、1H NMR、MS和元素分析得以证实。
A facile and general synthesis of a series of new tropolone-based chalcone compounds by Claisen-Schmidt condensation reaction from 3-acetyl-5-bromotropolone and substituted benzaldehydes was described. The method using 5% aq. KOH as catalyst and 50% aq. methanol as solvent was attractive since it specifically generates(E)-isomers with high yields under mild reaction conditions. The structures of the title compounds were characterized by IR,IH NMR,and MS techniques.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2012年第12期1848-1852,共5页
Chemical Research and Application