摘要
目的:从临床实例出发,探讨克林霉素致味觉异常的临床特点及原因,为临床合理用药提供参考。方法:报道我院注射用克林霉素致味觉异常1例,并通过检索1994-2011年国内医药期刊报道的相关文献进行综合分析。结果:综合文献报道及我院1例克林霉素致味觉异常共12例患者的一般情况、给药方案、发生时间、处理及结果后,提示口服、肌内注射和静脉滴注给药均可导致味觉异常,发生时间为给药10 min以内至用药2 d后,其中9例为qd给药,5例单次剂量偏大,不符合该药说明书的规定。经停药或更换药物后,该不良反应预后较好。结论:克林霉素所致味觉异常与使用剂量和给药频次可能有一定的相关性,临床应重视该不良反应,严格掌握用法用量,确保用药安全。
Objective: To investigate the clinical characteristics and causes of elindamyein-induced allot- riogeusia from clinical practice, and to provide reference for rational drug use in clinic. Methods: One case of allotriogeusia occurred in our hospital was reported, which was possibly induced by clindamycin. Literature of clin- damycin-induced allotriogeusia in domestic pharmaceutical journals from 1994 to 2011 was collected and analyzed statistically. Results: The clinical information of dosage regimen, onset time, treatment methods and efficacy in 12 patients with allotriogeusia reported in our hospital and literature were analyzed. Clindamycin-induced allotriogeusia occurred following oral administration, intramuscular injection and intravenous infusion; the onset time was within 10 minutes to 2 days after medication. In 9 patients, the administration intervals were once daily; in 5 patients, the single doses were too large, which did not comply with the dosage of the drug instructions. The prognosis was better after withdrawal or replacement of the drugs. Conclusion: Clindamycin-induced allotriogeusia seems to correlate to the dosage and dosing frequency. More attention should be paid to clindamycin-induced allotriogeusia, and clinical application should comply with the usage and dosage to ensure the safety of drug use.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2012年第23期2826-2828,共3页
Chinese Journal of New Drugs
关键词
克林霉素
不良反应
味觉异常
文献分析
合理用药
clindamycin
adverse drug reactions
allotriogeusia
literature analysis
rational drug use