克林霉素致味觉异常1例并文献分析

One case of clindamycin-induced allotriogeusia and analysis of the relevant literature

目的:从临床实例出发,探讨克林霉素致味觉异常的临床特点及原因,为临床合理用药提供参考。方法:报道我院注射用克林霉素致味觉异常1例,并通过检索1994-2011年国内医药期刊报道的相关文献进行综合分析。结果:综合文献报道及我院1例克林霉素致味觉异常共12例患者的一般情况、给药方案、发生时间、处理及结果后,提示口服、肌内注射和静脉滴注给药均可导致味觉异常,发生时间为给药10 min以内至用药2 d后,其中9例为qd给药,5例单次剂量偏大,不符合该药说明书的规定。经停药或更换药物后,该不良反应预后较好。结论:克林霉素所致味觉异常与使用剂量和给药频次可能有一定的相关性,临床应重视该不良反应,严格掌握用法用量,确保用药安全。

Objective： To investigate the clinical characteristics and causes of elindamyein-induced allot- riogeusia from clinical practice, and to provide reference for rational drug use in clinic. Methods： One case of allotriogeusia occurred in our hospital was reported, which was possibly induced by clindamycin. Literature of clin- damycin-induced allotriogeusia in domestic pharmaceutical journals from 1994 to 2011 was collected and analyzed statistically. Results： The clinical information of dosage regimen, onset time, treatment methods and efficacy in 12 patients with allotriogeusia reported in our hospital and literature were analyzed. Clindamycin-induced allotriogeusia occurred following oral administration, intramuscular injection and intravenous infusion; the onset time was within 10 minutes to 2 days after medication. In 9 patients, the administration intervals were once daily; in 5 patients, the single doses were too large, which did not comply with the dosage of the drug instructions. The prognosis was better after withdrawal or replacement of the drugs. Conclusion： Clindamycin-induced allotriogeusia seems to correlate to the dosage and dosing frequency. More attention should be paid to clindamycin-induced allotriogeusia, and clinical application should comply with the usage and dosage to ensure the safety of drug use.