深圳市万名流动妇女HPV感染现状分析

Analysis of infection of HPV among 10000 female migrant population in Shenzhen.

目的通过对深圳市万名流动妇女生殖道人乳头瘤病毒(HPV)的检测,对不同型别HPV的感染状况及分布情况进行分析,为流动妇女宫颈癌筛查寻找参考依据。方法对深圳市各区符合条件的妇女采集宫颈脱落细胞,采用基质辅助激光解析电离飞行时间质谱技术(MALDI-TOF-MS)对宫颈脱落细胞进行HPV分型检测。结果深圳市10 082名流动妇女HPV总感染率为7.5%,HPV的16种型别均有检出。感染最多的型别依次是HPV16(1.4%),HPV52(1.2%),HPV58(1.0%)。感染率在各年龄段、各职业、各教育程度和不同的性生活年限的分布中皆有显著性的差异。结论对流动妇女进行HPV基因分型检测,了解流动妇女HPV感染现状,有利于国家制定良好的宫颈癌筛查政策。

Objective To screen the infection status and distribution of different types of cervical human papillomavirus （HPV） in 10000 migrant women＇s genital tracts in Shenzhen and to provide references for the migrant population screening. Methods 10 082 women in Shenzhen were recruited by using the random sampling methods. Matrix-assisted laser desorption ionization time of flight the Accounting mass spectrometry （MALDI-TOF-MS） technology were used on cervical ceils for HPV detection and genotyping. Results Among the 10082 women, 759 were in- fected with HPV, accounting for 7.5% （759/10082）. 16 HPV types were detected. The top 3 highest infection type were HPV16 （1.4%）, HPV52 （1.2%）, HPV58 （1.0%）. There were significant differences of the infection rates on different ages, different occupations, different levels of education, and different sexual life of years. Conclusion By detecting the HPV genotyping, the research concludes the HPV infection status of migrant women, and be helpful the policy making against cervical cancer.