2986株临床病原菌的分布与耐药性分析

Analysis of 2986 Strains of Clinical Pathogens Distribution and Resistance to Antibiotics

目的:分析江苏大学附属医院2011年临床分离菌的构成及耐药性的动态变化。方法:从2011年1—12月住院患者送检培养的各类标本中分离出的病原菌的分布、构成及耐药性情况进行统计,综合分析医院病原菌检出的特点及耐药情况。结果:分离出2986株病原菌,主要来自痰液、血液标本,其分离率为75.69%;分离菌以革兰阴性杆菌为主(75.12%),依序为铜绿假单胞菌(16.31%)、鲍曼不动杆菌(15.77%)、大肠埃希菌(12.19%)、肺炎克雷伯菌(11.69%);革兰阳性杆菌以金黄色葡萄球菌为主(10.82%);高度耐药及多重耐药菌中,产ESBL细菌包括大肠埃希菌、肺炎克雷伯菌为103株,其检出率占总检出病原菌的3.5%;耐苯唑西林金黄色葡萄球菌(MRSA)为214株,占总检出病原菌的7.2%。结论:检出的细菌耐药率较高,需加强耐药监测,采取有效措施积极地控制病原菌感染。

Objective： To analyze the distribution and the dynamic change of resistance of clinical isolates in the Hospital Affilialed to Jiangsu University in 2011. Methods： To comprehensively analyze the detection characteristics of hospital pathogens and dl-ug resistance based on the statistics of the distribution, formation and resistance of pathogens isolated from various specimens from hospitalized patients from January to December in 2011. Results： The 2 986 strains of pathogenic bacteria were isolated, mainly from sputum and blood specimens of the isolation rate were the highest （75.69%）; isolated bacteria were mainly gram-negative bacteria（75.12%）, followed by Pseudomonas aeruginosa （16.31%）, Acinetobacter baumannii （ 15.77% ）, Escherichia coli （12.19%） and Pneumonia Klebsiella （ 11.69%）; Gram-positive bacteria were mainly Staphylococcus uureus （10.82%）. High resistance and multiple antibiotic resistant bacteria, produce ESBL bacteria including Escherichia coli, Pneumonia Klebsiella bacteria were 103 strains, the total detection rate of the pathogen was 3.5%; MRSA were 214 strains, accounting tbr 7.2% of total samples of the pathogen. Conclusions： the resistance of bacteria detected by our hospital is high, so the resistance monitoring is strongly required to take effective measures to actively control the pathogen infection.