静脉药物配置环境下13种中药注射剂配置后不溶性微粒的测定

Injections in Pharmacy Intravenous Admixture Service

目的:测定13种中药注射液在静脉药物配置环境下配置后在不同时间及不同药物浓度中的不溶性微粒。方法:模拟临床输液配置操作过程,对浙江省中医院临床常用中药注射液配置后,采用2010版《中华人民共和国药典》规定的不溶性微粒检查法——光阻法,测定进入病人静脉前液体中不溶性微粒的数量。结果:药物配置后的不溶性微粒数目受多种因素的影响,药物浓度增大,不溶性微粒数增多;输液配置完毕后,放置时间越长,不溶性微粒数越多。结论:我们在配置静脉输液时要根据临床规定用量,控制药物的浓度,不宜过大;输液配置完毕后要尽快用于病人,减少输液的放置时间。

Objective ：To detect the insoluble particles in 13 kinds of traditional Chinese medicine injections in Phar- macy Intravenous Admixture Service （PIVAS） at different times and different drug concentrations. Methods：The solutions were prepared following the procedures in routine clinical practice, and the quantity of insoluble particles in these solutions were measured before the solutions entering the intravenous of patients by light blockage method specified in China Phar-macopeia （2010 edition）. Results：The number of insoluble particles after drug compatibility was affected by several fac tors. Conclusion：It＇s necessary to tighten control on the quality of traditional Chinese medicine injections.