健脾散结丸用于恶性肿瘤化疗后脾虚证的58例临床观察

Clinical Observation on Spleen Deficiency after Chemotherapy of Malignant Tumors Treated by Pills for Invigorating Spleen and Eliminating Stagnation

目的:观察健脾散结丸治疗恶性肿瘤化疗后引起的脾虚证患者的疗效并且进行安全性评价。方法:58例恶性肿瘤化疗后出现脾虚证的患者,症见倦怠乏力,食少纳呆,脘腹痞满,胸膈烦闷,恶心呕吐,腹胀便秘。舌淡或淡暗,苔厚,脉弦细或沉细,化疗结束后开始口服健脾散结丸(浓缩丸),1次10g,1日2次,共14天。14天后评价疗效,记录患者在疗前、第3、7、10、14天时的脾虚各证候评分、舌苔、脉象的变化及评分,记录患者的卡氏评分及体重变化的评分;在化疗结束开始服药及服药后第7、14天分别测定患者的血尿便常规、肝肾功、心电图以评价药物的安全性。结果:恶性肿瘤化疗后出现脾虚证的患者,口服健脾散结丸后,治疗后患者的脾虚证候的总评分及脾虚各证候的评分较治疗前有显著性差异;卡氏评分及体重评分无显著性差异;无明显不良反应。结论:健脾散结丸用于恶性肿瘤化疗后出现脾虚证候的患者口服后,患者脾虚证候有明显改善,说明该药物可以改善患者临床症状,提高患者生存质量,用于临床相对较为安全。

Objective ： To observe the efficacy and safety of the Chinese medicine pills for invigorating spleen and e liminating stagnation on patients who had spleen deficiency after the chemotherapy of the malignant carcinoma. Methods ： 58 patients with the syndromes of the spleen deficiency were collected. At the end of the chemotherapy cycle,the patients began to take the pills for 14 days. On the 0,3rd,7th, 10th and 14th day, according to the standards,the symptoms and some indexes were detected, such as liver and kidney function to evaluate the toxicity of the medicine. When 14 days fin ished ,the whole efficacy was measured and then appreciated. Results ：The patients with malignant carcinoma who had syndromes of spleen deficiency after chemotherapy, their general manifestations after treatment had more significant differ ences than pre -treatment. Conclusion： The pills could be effective for the patients with the spleen deficiency after the chemotherapy cycle. The medicine could help patients out of the enteric side - effects of the treatment and improve the life quality. It could be helpful for the patients to recover from the chemotherapy.