正常妊娠早期妇女HbA_1c水平调查的研究

Investigation of HbA_1c level in early normal pregnant women

目的了解正常妊娠早期妇女HbA1c的水平,为妊娠糖尿病(GDM)的早期诊断提供理论基础。方法纳入468例妊娠8～14周孕妇,另纳入125名正常非孕育龄妇女,两组均测定BMI、血红蛋白(Hb)、平均红细胞体积(MCV)、FPG及HbA1c进行组间比较。结果非孕育龄妇女HbA1c水平为(5.45±0.31)%,正常妊娠早期妇女为(5.12±0.25)%,两组间差异有统计学意义(P<0.05)。正常妊娠早期妇女HbA1c水平与年龄、FPG呈正相关(r=0.15,0.25),与MCV呈负相关(r=-0.21),与Hb及BMI无相关性(P>0.05)。结论正常妊娠早期妇女HbA1c的水平低于正常非孕育龄妇女,提示其控制上线为5.6%,当大于此值时可能需早期进行干预或按GDM管理治疗。

Objective To explore the HbA1 c level in early normal pregnancy to provide theoretical basis for the diagnosis of gestational diabetes mellitus （GDM）. Methods The 468 normal pregnant women were carded out jointly by determination of age, BMI, hemoglobin （Hb）, mean red cell volume （MCV）, FPG, and HbAlc. The data were statistically processed. In addition, the 125 healthy non-preg- nant women with the same determinations were attributed into the control group for comparison. Results The level of HbAlc was （5.45±0. 31）% in healthy non-pregnant women, and （5. 12±0. 25） % in early pregnant women P〈0. 05. The level of HbA1 c in early pregnant women was positively correlated to age and FPG （r=0. 15,0. 25）, negatively correlated to MCV （r=-0. 21）, and not correlated to Hb and BMI （P〉0. 05）. Conclusion The HbA1 c level is lower in early normal pregnant women than in healthy non- pregnant women, suggesting that control target is 5.6%, and more than 5.6% need interference or man- agement.