12-羟基二十碳四烯酸与2型糖尿病合并冠心病的相关分析

Association between 12-Hydroxyeicosatetraenoic acid and coronary heart disease in T2DM patients

目的探讨12-羟基二十碳四烯酸(12-HETE)在T2DM合并冠心病(CHD)中的作用。方法测定109例T2DM非CHD患者(T2DM)组,152例T2DM合并CHD患者(CHD)组和103名健康对照者(NC)组的12-HETE水平。结果 T2DM组和CHD组的12-HETE水平高于NC组(P<0.01),且CHD组高于T2DM组(P<0.01)。T2DM组和CHD组的12-HETE均与Gensini积分相关(r=0.430,P=0.001;r=0.371,P=0.001)。结论 12-HETE可能与糖尿病合并CHD的发生有关。

Objective To study the relationship between 12-Hydroxyeicosatetraenoic acid （12- HETE） and coronary heart disease （CHD） in T2DM patients. Methods The level of 12-HETE was detected in 109 cases of T2DM without CHD, 152 cases of T2DM with CHD, and 103 healthy adults. Results The level of 12-HETE was higher in T2DM and CHD groups than in the control group （P〈 0. 01）, and it was higher in CHD group than in T2DM group （P〈0. 01）. The level of 12-HETE was correlated with Gensini score in both groups （r=0. 430, P=0. 001; r=0. 371, P=0. 001）. Conclusion 12-HETE plays a role in the development of CHD in T2DM patients.