旋覆代赭汤对不同证型糖尿病胃轻瘫患者促胃动力的研究

Research on Xuanfu Daizhe Decoction′s Ability on Improving Gastric Motility of Different Types of Diabetic Gastroparesis(DGP)Patients

目的:观察旋覆代赭汤在不同证型糖尿病胃轻瘫(Diabetic gastroparesis,DGP)患者促胃肠动力的研究。方法:将78例患者分为肝胃不和、胃热津伤和脾胃虚弱等3组:均应用大剂量旋覆代赭汤(一两为15.625g)治疗,每日1剂,连用4周。免疫组化法观察各组治疗前后血浆中胃动素(MOT)、血管活性肠肽(VIP)、胃泌素(GAS)的分布变化。结果:脾胃虚弱组血浆中MOT的含量显著升高(P<0.01)、VIP的表达明显减少(P<0.01)、血浆GAS表达显著降低(P<0.01),与其他两组具有统计学差异。结论:旋覆代赭汤的促胃肠动力作用在脾胃虚弱组最明显。

Objective ：To observe Xuanfu Daizhe Decoction＇s ability on improving gastric motility of different types of diabetic gastroparesis （DGP）patients. Methods ：78 patients were divided into 3 groups：liver and stomach disharmony group（ group 1 ） ,body fluid damage due to stomach-heat group （group 2）, weakness of stomach and spleen group （group 3 ）. The bigger dose（ 1 Liang = 15. 625g） of Xuanfu Daizhe Decoction was used for three of the groups ,one dosage a day ,consecutively for 4 weeks. The immunohistochemistry method was used to observe the distribution changes of MOT, VIP and GAS in the plasma before and after the treatment. Results ： Group 3 had obvious increase of MOT in plasma（ P 〈 0. 01 ）, VIP expression decreased obviously （ P 〈 0. 01 ）, and GAS expression decreased obviously （ P 〈 0. 01 ）, which had statistics difference from the other 2 groups. Conclusion： The effect of Xuanfu Daizhe Decoction on improving gastric motility is the most obvious in weakness of stomach and spleen group.