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血管内皮细胞迁移与肿瘤血管生成 被引量：2

Vascular endothelial cell migration and tumor angiogenesis
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摘要 肿瘤生长和转移均依赖于肿瘤的血管生成，而血管内皮细胞迁移是肿瘤血管生成过程的一个重要环节，有着重要的研究意义。现从肿瘤血管生成过程中促血管生成因子、骨架蛋白解聚、细胞外基质的降解三个方面对血管内皮细胞迁移的影响进行综述。 Tumor growth and metastasis depend on tumor angiogenesis. Vascular endothelial cell migration is an important part of the tumor angiogenesis process, has an important significance. Now the three aspects of the vascular endothelial cell migration in tumor angiogenesis： pro-angiogenic factors, cytoskeletal proteins depolymerization,extraeellular matrix degradation are reviewed.
作者 胡赞 胡成平 李敏
机构地区 中南大学湘雅医院呼吸内科(呼吸与危重症医学科)
出处 《国际呼吸杂志》 2012年第22期1751-1755,共5页 International Journal of Respiration
关键词 血管内皮细胞迁移 肿瘤血管生成 促血管生成因子 骨架蛋白 细胞外基质 Vascular endothelial cell migration Tumor angiogenesis Pro angiogenic factors Cytoskeletal proteins Extracellular matrix degradation
分类号 R730.2 [医药卫生—肿瘤]
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参考文献29

  • 1Lamalice L, Le Boeuf F, Huot J. Endothelial cell migration during angiogenesis. Circ Res, 2007,100 : 782-794.
  • 2王靖雯,刘涛,王伟,杨林青,程建新.uPA、VEGF和微血管密度在卵巢恶性生殖细胞肿瘤中表达及其临床意义研究[J].中华实用诊断与治疗杂志,2011,25(6):548-551. 被引量：8
  • 3Ochi N, Matsuo Y, Sawai H, et al. Vascular endothelial growth faeto:C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis, Pancreas, 2007, 34:444- 451.
  • 4Yoshizuka N, Chen RM, Xu Z,et al. A novel function of pa8 regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Mol Cell Biol, 2012,32 : 606-618.
  • 5Prager GW, Breuss JM, Steurer S,et al. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial ceils. Blood,2004,103:955-962.
  • 6赵宝生,李汉臣,刘尚国,刘彦轩,秦秀广,齐博.Ang-2在食管鳞癌中表达及与血管生成的研究[J].中华全科医学,2010,8(2):140-142. 被引量：1
  • 7李白翎,张冠鑫,侯霄雷,等.沉默血管内皮生长因子及促血管生成素2基因抑制裸鼠人肺腺癌移植瘤生长的实验研究.中华临床医师杂志(电子版),201l,5:3756-3762.
  • 8Cai M, Zhang H, Hui R. Single chain Fv antibody against angiopoietin-2 inhibits VEGF induced endothelial eel proliferation and migration in vitro. Biochem Biophys Res Commun, 2003,309 : 946-951.
  • 9Cascone I, Audero E, Giraudo E, et al. Tie-2 dependent activation of RhoA and Racl participates in endothelial cell motility triggered by angiopoietin-1. Blood, 2003, 102: 2482- 2490.
  • 10Yuan HT, Khankin EV, Karumanchi SA,et al. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol, 2009,29 : 2011-2022.

二级参考文献26

  • 1单保恩,潘立峰,李巧霞,王俊霞.血管内皮生长因子在食管癌组织中的表达及其临床意义研究[J].肿瘤防治研究,2005,32(10):644-647. 被引量：12
  • 2Ogawa M ,Yamamoto H. Hepatic expression of Ang-2 RNA in metastat- ic colorectal cancer[ J]. Hepatology,2004,39(2) :528-539.
  • 3Ochiumt T, Tanaka S, Oka S, et al. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma[ J]. Int J Onco1,2004,24 (3) :539-547.
  • 4Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis : a new significant and independent prognostic indicator in early-stage breast carcinoma[J]. J Natl Cancer Inst,1992,84(24) :1875-1887.
  • 5Li LY, Barlow KD, Metheny-Barlow LJ. Angiopoietins and Tie2 in health and disease [ J ]. Pediatr Endocrinol Rev, 2005,2 ( 3 ) : 399- 408.
  • 6Krikun G, Schatz F, Finlay T, et al. Expression of angiopoietin-2 by human endometrial endothelial cells:regulation by hypoxia and inflammation[J]. Biochem Biophys Res Commun,2000,275 (1) :159.
  • 7Hu B, Jarzynka M J, Guo P, et al. Angiopoietin 2 induces ghoma cell invasion bystimulating matrix metalloprotease 2 expression through the alphavbetal integrin and focal adhesion kinase signaling pathway[J]. Cancer-Res,2006,66( 11 ) :775-783.
  • 8Holash J, MaisWipierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angioietins and VEGF[ J]. Science, 1999,284 (5422) : 1994-1998.
  • 9Lobov IB, Broobs PC, Lang RA. Angiopoietin-2 displaysVEGF-dependent modulation of capillary structure and endothelial cell survival in vivo[J]. Proc Nati Acad Sci USA,2002,99(17) :11205-11210.
  • 10Wojtukiewicz M, Sierko E, Zacharski L R, et al. Occurrence of components of fibrinolytic pathways in situ in laryngeal cancer [J]. Semin Thromb Hemost,2003,29(3) :317 -320.

共引文献12

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国际呼吸杂志
2012年 第22期

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