紧密连接蛋白occludin与肺部疾病关系的研究进展被引量：1

Tight junction protein occludin and lung disease reaearch progress

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摘要紧密连接（tight junction，TJ）是正常上皮细胞或内皮细胞间机械屏障的重要结构基础，由多种蛋白质组成，呈连续带状分布，连接相邻的细胞，在维持机体内环境的稳定和发挥机体正常生理功能等方面具有重要作用。Occludin蛋白是紧密连接中重要的结构蛋白，本文就occludin蛋白的结构与功能、调控机制及其与肺部疾病关系的研究进展作一综述。 Tight junction （TJ）, which consists of a variety of proteins, is an important structural basis of the normal epithelial cells or endothelial cell mechanical barrier. TJ is continuous belt distributed, connects adjacent cells and plays an important role in maintaining the stability of inner environment and playing the normal physiology function and so on. Occludin protein is an important structural protein in TJ. This paper makes a review of oecludin protein about its structure, the ruction, tegulation mechanism and the relationship with lung diseases.

作者陈春梅王宋平

机构地区泸州医学院附属医院呼吸一科

出处《国际呼吸杂志》 2012年第23期1829-1832,共4页 International Journal of Respiration

关键词紧密连接 OCCLUDIN蛋白肺部疾病 Tight junction Occludin Lung disease

分类号 R285.5 [医药卫生—中药学]

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