摘要
目的探讨不同分期非小细胞肺癌患者血清中TNF-α水平的变化及其临床意义。方法选择初治非小细胞肺癌患者60例(肺癌组,其中鳞癌38例、腺癌22例,Ⅰ+Ⅱ期14例、Ⅲa期17例、Ⅲb+Ⅳ期29例)与体检健康者62例(对照组)。采用双抗体夹心酶联免疫吸附(ELISA)法测定所有受试者血清TNF-α水平。结果肺癌组患者血清中TNF-α水平显著升高,与对照组相比差异有统计学意义(P<0.001)。不同病理类型肺癌患者血清TNF-α水平差异不明显,腺癌与鳞癌相比差异无统计学意义(P>0.05)。随着病情进展,肺癌患者血清TNF-α水平有逐渐增高的趋势,各临床分期肺癌患者血清TNF-α水平相比差异均有统计学意义(P<0.05或P<0.001)。结论血清TNF-α水平检测对非小细胞肺癌的辅助诊断、疾病分期及活动情况具有重要的临床意义,可为非小细胞肺癌患者的机体免疫状态及预测疾病发生、发展提供参考。
ABSTRACT： Objective To investigate the changes in serum TNF-α levels in patients with non- small cell lung cancer and their clinical significance. Methods Serum TNF-α levels were detected by ELISA in 60 patients with non-small cell lung cancer （squamous cell carcinoma in 38 and adenoc- arcinoma in 22; stage Ⅰ ＋ Ⅱ in 14, stage Ⅲa in 17 and stage Ⅲb＋IV in 29）and 62 healthy controls. Results Compared with healthy controls, serum TNF-α levels significantly increased in lung cancer patients（P〈0.001 ）. There were no obvious differences in TNF-α levels between patients with squamous cell carcinoma and patients with adenocarcinoma（P〉0.05）. Furthermore, serum TNF-α levels increased with the disease progress in patients,there were significant differences in TNF-α levels were found among different stages of non-small cell lung cancer （P〈0.05 or P〈0.001 ）. Conclusion The detection of serum TNF-α levels has important clinical significance in the assisted diagnosis, disease staging and activities of non-small cell lung cancer, and can provide references for evaluating immune status and predicting disease development.
出处
《实用临床医学（江西）》
CAS
2012年第10期22-23,27,共3页
Practical Clinical Medicine
