摘要
目的探讨奥扎格雷钠对非ST段抬高型心肌梗死患者血液流变学、血栓素B2（TXB2）和6-酮-前列腺素F1α（6-K—PGF1α）的影响。方法60例非卵段抬高型心肌梗死患者，完全随机分为观察组和对照组，各30例。对照组使用单硝酸异山梨酯，20mg／d，静脉滴注，第1～14天；低分子肝素5000U，2次／d，皮下注射，第1—7天；辛伐他汀10mg／d，15服。观察组在对照组基础上加用奥扎格雷钠，80mg／d，静脉滴注，1次／d。2组均2周为1个疗程。观察2组临床疗效、治疗前后血液流变学指标、TXB2、6-K—PGF1α。变化情况。结果观察组治疗后血液流变学各项指标均较治疗前明显降低（P〈0．05），观察组治疗后各项血液流变学指标明显低于对照组治疗后（P〈0．05）。观察组治疗前、后TXB2分别为（930±113）、（532±54）ng／L，6-K—PGFl。分别为（190±21）、（327±32）ng／L；对照组TXB2分别为（9354-98）、（777±77）ng／L，6-K—PGF1α。分别为（190±18）、（217±23）ng／L；2组治疗后TXB2和6-K—PGF1α。均明显高于治疗前，观察组治疗后高于对照组治疗后，差异均有统计学意义（均P〈0．05）。结论奥扎格雷钠能显著改善非卵段抬高急性心肌梗死患者的血液流变学指标，纠正TXB2／6-K—PGF1α。动态平衡。
Objective To investigate the effect of sodium ozagrel on hemorheology and thromboxane B2 （ TXB2 ） and 6-keto-prostaglandin F1 （ 6-K-PGF1α ） in patients with non-ST-segment elevation acute myocardial infarction. Methods Totally sixty patients with non-ST-segment elevation myocardial infarction were randomly divided into treatment group and control group. The control group using isosorbide mononitrate, low molecular weight heparin and simvastatin. Treatment group used ozagrel with 2 weeks as a course of treatment. The changes of clinical efficacy, hemorheology, TXB2 and 6-K-PGF~ were observed. Results After treatment, the hemorheological parameters significantly were lower than those before treatment （ P 〈 0.05 ）. In control group after treatment, whole blood viscosity （high shear） , platelet adhesion rate and fibrinogen level were significantly lower than those before treatment （P 〈 0.05 ）. After treatment, hemorheology was significantly lower than that in the control group after treatment （P 〈 0. 05 ）. In the two groups, TXB2 were significantly decreased （ P 〈 0. 05 ） after treatment ; 6-K-PGFlα were significantly increased （ P 〈 0.05 ） after treatment. Conclusions Ozagrel can significantly improve the non-ST-segment elevation acute myocardial infarction in patients with hemorheology.
出处
《中国医药》
2012年第12期1493-1494,共2页
China Medicine
