肝细胞肝癌化疗栓塞术后疗效与CD34的表达及意义

Efficacy after cells liver cancer chemoembolization and significance of CD34 expressions

目的:回顾性分析肝细胞癌中CD34的表达与化疗栓塞术效果的关系。方法:对25例B超穿刺诊断为肝细胞癌,选择介入治疗的标本标记CD34,分析其免疫组化的表达与化疗栓塞术治疗后肿瘤碘油沉积情况及栓塞次数的关系。结果:肿物大小2～10cm,癌组织血窦样间质中,CD34均有表达,但阳性细胞的密度不一。经导管肝动脉化疗栓塞第一疗程常规连续治疗3次,25例中有4例2次治疗后复查CT显示碘油沉积良好,增强扫描未见肿瘤供血,未连续做第三次,3例连续治疗5次。随访4年,死亡22例,生存3例。结论:CD34的阳性表达与患者的生存无明显相关性,与治疗的次数及复发的时间有关。

Objective：To analysis the relation between the expressions of CD34 in liver cell cancer and the effect of chemoembolization. Methods ：Twenty-five cases with liver cell cancer puncture diagnosed by B ultrasonic,mark the interventional therapy specimen with CD34,analysis the relation between the expressions of immunohistochemistry and the sedimentary situation of cancer lipiodol with the embolism times. Results ：The size of tumor is 2-10 cm,there is CD34 expressions in cancer tissue sinusoids stroma,but the density of masculine cells is different. After first 3 suc- cessive conventional treatment with duct liver artery chemoembolization,4 cases out of 25 show good sedimentary sit- uation of lipiodol in CT re-inspection after two treatments ,there is no vascularity supply in strengthen scan,no three successive treatments, 3 cases with 5 treatments. After 4 years follow-up ,there are 22 deaths and 3 survivals. Conclu- sion..The survive of patients is not obviously related with the masculine expression of CD34,but related with the times of treatment and time of relapse.