摘要
目的:通过对初诊2型糖尿病患者尿PCX,Nephrin及单核细胞趋化蛋白-1(MCP-1)进行检测,探讨三者对早期糖尿病肾病的预测价值。方法:选择2011年5月—2011年12月住院初诊2型糖尿病患者132例,正常对照(N)组36例,尿白蛋白/尿肌酐(UAlb/UCR)<30 mg/g为糖尿病(DM)组56例,UAlb/UCR≥30 mg/g为糖尿病肾病(DN)组76例。检测尿PCX(UPCX),Nephrin(UNephrin),MCP-1(UMCP-1),白蛋白(UAlb)及尿肌酐(UCR)。比较各组UPCX/UCR,UNephrin/UCR,UMCP-1/UCR的差异及2型糖尿病患者上述各指标间的相关性及与UAlb/UCR的相关性,计算糖尿病患者UMCP-1/UCR,UNephrin/UCR,UPCX/UCR及三者联合检测的阳性率,并与UAlb/UCR的阳性率进行比较分析。结果:UPCX/UCR,UMCP-1/UCR水平糖尿病组分别为(37.37±22.83)μg/g和(47.19±29.98)ng/g,比正常对照组明显升高(P<0.05);UAlb/UCR,UPCX/UCR和UMCP-1/UCR水平DN组比DM组和正常对照组明显升高(P<0.05);UNephrin/UCR水平DN组较DM组明显升高(P<0.05)。2型糖尿病患者UPCX/UCR,UMCP-1/UCR和UNephrin/UCR水平与UAlb/UCR呈正相关(r=0.619;0.568;0.535)(P<0.05);UPCX/UCR水平与UMCP-1/UCR和UNephrin/UCR呈正相关(r=0.799;0.718)(P<0.05),UNephrin/UCR水平与UMCP-1/UCR水平呈正相关(r=0.635,P<0.05);UMCP-1/UCR,UNephrin/UCR and UPCX/UCR的阳性率较UAlb/UCR显著升高(χ2=9.818,6.673,5.395,P<0.05)。结论:尿PCX,Nephrin和MCP-1单独或联合检测在早期糖尿病肾病诊断中具有重要的应用价值。
Objective：To explore the predictive value of detect urinary PCX,Nephrin and MCP-1（MCP-1） for dia- betic nephropathy in newly diagnosed type 2 diabetic patients. Methods ：One hundred and thirty-two newly diagnosed T2DM patients from May to November in 2011.36 cases in control group,cases of urine albumin/creatinine in urine （UAlb/UCR） 〈30 mg/g in diabetes mellitus （DM group）, cases of cases of UAlb/UCR ≥ 30 mg/g in diabetic nephropathy （DN group）. The urinary PCX （UPCX）, Nephrin （UNephrin） MCP-1 （UMCP-1）, UAlb and UCR were measured. To compare the difference of UPCX/UCR ,UNephrin/UCR ,UMCP-1/UCR in every group ,the pertinency of these index of T2DM patients and UAlb/UCR. The comparison among positive rate of UMCP-1/UCR,UNephrin/ UCR,UPCX/UCR and UAlb/UCR were investigated in T2DM patients. Results：The UPCX/UCR,UMCP-1/UCR level were significantly higher in DM group than in healthy subjects （P〈0.05）. The UAlb/UCR, UPCX/UCR and UMCP-1/UCR were significantly higher in DN group than in DM group and in control group （P〈 0.05）：the UN- ephrin/UCR level was significantly higher in DN than in DM（P〈0.05）. The UPCX/UCR,UMCP-1/UCR and UN- ephrin/UCR level was positively correlated with UAlb/UCR（r=0. 619,0. 568 and 0. 535 respectively）（P〈0. 05） in T2DM patients. The UPCX/UCR level was positively correlated with UMCP-1/UCR and UNephrin/UCR levels（r= 0. 799 and 0. 718 respectively）（P〈0.05）. The UNephrin/UCR level was positively correlated with UMCP-1/UCR level （r= 0. 635,P〈0.05）in T2DM patients. The positive rate of UMCP-1/UCR,UNephrin/UCR and UPCX/UCR were significantly higher than that of UAlb/UCR （χ2= 9. 818,6. 673 and 5. 395 respectively,P〈0.05） in T2DM pa- tients. Conclusion：Urinary PCX,Nephrin and MCP-1 can act as predictors of the early renal damage in newly diag- nosed type 2 diabetic patients.
出处
《临床医药实践》
2012年第12期933-938,共6页
Proceeding of Clinical Medicine
