间质流膏治疗特发性间质性肺炎30例

Therapeutic Effect of Jianzhi Fluid Extract in Treatment of Idiopathic Interstitial Pneumonia: A Report of 30 Cases

目的观察间质流膏治疗特发性间质性肺炎(idiopathic interstitial pneumonia,IIP)的临床疗效。方法将60例IIP患者随机分为间质流膏组与激素组,分别采用间质流膏、强的松治疗12周,观察患者治疗前后临床、影像、生理评分(clinical,radiologic,and physiological score,CRP)及血清转化生长因子-β1(trans-forming growth factor-β1,TGF-β1)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的改变。结果两组治疗后CRP评分及TGF-β1、TNF-α水平均较治疗前显著下降(P<0.01)。间质流膏组CRP评分及TGF-β1、TNF-α水平均显著低于激素组(P<0.01)。结论间质流膏较单纯激素治疗可有效改善IIP患者临床症状,提高生存质量,并能显著降低患者血清TGF-β1、TNF-α水平。

Objective To observe the therapeutic effect of Jianzhi fluid extract in the treatment of idiopathic interstitial pneumonia （IIP）. Methods Sixty IIP patients were randomly divided into Jianzhi fluid extract group and hormone group. The Jianzhi fluid extract group was treated with Jianzhi fluid extract, while the hormone group was treated with prednisone. The length of treatment course was 12 weeks in both groups. The therapeutic effect was assessed based on clinical, radiological, and physiological （CRP） scores and serum levels of transforming growth factor-β1 （TGF β1） and tumor necrosis factor-α （TNF-α） before and after treatment. Results Both groups showed significantly decreased CRP scores and serum levels of TGF-β1 and TNF-α after treatment （P〈0.01）. All the indices were significantly lower in the Jianzhi fluid extract group than in the hormone group （P 〈0. 01）. of life, and Jianzhi fluid extract is superior to hormone treatment in relieving clinical symptoms, improving quality notably decreasing serum TGF-β1 and TNF-α levels in IIP patients.