环糊精超分子组装体的研究进展

Progress on the Supramolecular Assemblies of Cyclodextrins

环糊精是由若干个D-吡喃葡萄糖单元通过α-1,4-糖苷键连接而成的环状低聚糖,具有一个亲水性的外表面和一个疏水性的空腔。利用主客体相互作用,环糊精及其衍生物能够选择性地与大小匹配的疏水性客体分子形成各种超分子包合物。本文概述了环糊精的结构与性质,并介绍了近年来国内外以环糊精为基础的纳米粒子、水凝胶等超分子组装体的设计原理、作用机制、刺激响应及应用特点,并对环糊精超分子组装体的前景进行了展望。

Cyclodextrins （CDs） are cyclic oligosaccharides composed of D-glucose units that are joined by a-l, 4- glucosidic linkages, which contain a hydrophilic outer surface and a hydrophobic cavity. Cyclodextrin and its derivatives can form inclusion complexes with suitable hydrophobic guest molecules through host-guest interaction. This review describes the structure and property of the cyclodextrin and the design principles, mechanisms, stimuli responses, and applications of the supramolecular assemblies such as nanoparticles, hydrogels, etc, based on cyclodextrins in recent years.