原发性甲状腺功能亢进症合并甲状腺癌

Primary hyperthyroidism and concurrent thyroid cancer.

目的 探讨原发性甲状腺功能亢进症 (甲亢 )合并甲状腺癌的临床发病关系及其诊断、治疗和预后。方法 对 1973～ 1999年收治的经外科手术后病理证实为原发性甲亢合并甲状腺癌 (甲癌 ) 2 5例 ,结合文献复习进行临床分析。结果 本组发病率约 3.5 6 %。全组术前均给予抗甲状腺药物治疗。 16例出现甲状腺结节。全组病例甲状腺手术治疗后随访均未见甲亢或甲癌复发。结论 近年来原发性甲亢合并甲癌发病率有上升趋势 ,临床诊断较困难。多数病例靠术后病理诊断。合理的手术治疗效果良好 ,预后较好。

Objective To study the clinical relationship between primary hyperthyroidism and thyroid cancer and its diagnosis,treatment and prognosis.Methods 25 cases of primary hyperthyroidism concurring with thyroid cancer hospitalized during 1973 to 1999 were proved by postoperative pathology.Their data together with the literature concerned were analysed.Results The morbidity was 3 56%.All cases were given anti-thyroid drugs preoperatively.16 cases showed thyroid nodules and all cases were performed thyroidectomy.No hyperthyroidism nor thyroid cancer recurred during the follow-up.Conclusion The morbidity of coexistence of hyperthyroidism and thyroid cancer has been ascending these years.The clinical diagnosis is still difficult and chiefly depends on postoperative pathology.Rational surgical treatment can result in good effects and better prognosis.