摘要
目的:通过检测KISS-I及MMP-9在EMs患者增生期与分泌期子宫内膜中的表达及对比研究,探讨其临床意义及两者相关性。方法:通过免疫组化和图像分析法对KISS-I、MMP-9蛋白在EMs患者的ECE组(48例)、匹配的EUE组(30例)以及CE组(27例)中的表达进行定位和半定量分析。结果:①KISS-I、MMP-9在ECE组、EUE组以及CE组子宫内膜组织中表达清楚;②MMP-9表达顺序为:ECE组>EUE组>CE组,组间差异有统计学意义(P<0.05)。三组表达强度在不同的月经周期中无统计学差异(P>0.05);KISS-I表达顺序为:CE组>EUE组>ECE组,组间差异有统计学意义(P<0.05)。结论:KISS-I及MMP-9在EUE、ECE以及CE均有表达,且表达存在差异性,可能共同参与EMs患者发病过程中子宫内膜异位侵袭、种植的过程。
Objective：To detect the expression and distribution of KISS-I and MMP-9 proteins in eutopic and ectopic endometrial tissues from women with endometriosis and to investigate the pathogenesis of endometriosis. Methods： The expression levels and distribution of KISS-I and MMP-9 proteins in ECE group（48）, EUE group（30） and CE group（27） were detected by immunohistochemical methods and image analysis. Results：（1） KISS- I , MMP-9 in group ECE, group EUE and group CE endometrial tissues express clearly;（2）MMP-9 expression in the order： ECE group 〉EUE group 〉CE group, the difference between groups was statistically significant （ P〈0.05 ） ; three groups of expression intensity varies during the menstrual cycle had no significant difference （P 〉0.05） ; KISS-I expression was weak in the order： CE group 〉EUE group 〉ECE group, group difference has statistics significance （P〈0.05）. Conclusion ：KISS-I and MMP-9 in EUE, ECE and CE were expressed, and expression differences exist, may be common in patients with EMs in the pathogenesis of endometriosis invasiveness, planting process.
出处
《亚太传统医药》
2012年第12期5-7,共3页
Asia-Pacific Traditional Medicine
