血清肌钙蛋白T在非急性心肌梗死患者轻度升高的原因探讨

Study on the cause of slightly elevated cTnT in non-acute myocardial infarction patient

目的探索血清肌钙蛋白在非急性心梗患者轻度升高的机理。方法以ELISA方法检测患者血清中心肌肌钙蛋白T（cTnT），并用统计学方法分析其中32例cTnT轻度升高但临床无心梗症状，心电图正常患者血清cTnT值与其他生化指标的相关性，从32例患者的病理机理的共性及以上相关分析的结果分析CTnT轻度升高的原因。结果轻度升高的cTnT与肾功能的损伤存在明显相关性r（BUN／cTnT）＝0．580（P＜0．01）；r（EREA／cTnT）＝0．725（P＜0．01）；r（URIC/cTnT）＝0．411（P＜0．05），但与心肌酶系列的指标除LDH及HBDH外无明显相关性r（LKH/cTnT）=0．7564（P＜0．01）：r（HBDH/cTnT）＝0．720（P＜0．01）。结论cTnT为较心肌酶检测心肌损伤更敏感的指标，而其在一些疾病群体中轻度升高的机理有别于急性心肌梗死的快速严重升高的现象。

Objective To study the cause of slighily elevated cardiac Tropnion-T (cTnT) in non-acute myocardial infarction patient. Methods The values of cTnT were measured by the method of ELISA. Thirty-two cases of slighily cTnT-elevated pahents without sign of acute myocardial infaretion were analyzed by comparing the value of cTnT with other biochemical index values. Resul There was significantly positive correlation between cTnT values and the renal function index values.r (BUN/cT nT) =0.5796 (P<0.01 ): r (EREA/cTnT) =0.7252 (P<0.01 ): r (URIC/cTnT) =0.4105 (P<0.05 ) .Yet the slighdy elevated cTnT had no positive correlation with the values of myocedal enzymes except LDL and HBDH, r(LDL/cTnT) =0.7564 (P<0.01): (HBDH/cTnT) =0.7202 (P<0.01) .Concusion cTnT is a more sensitive index for myocardial damage and its slighily elevating is different from rapidly and seriously elevating in acute myocardial infarction.