再生障碍性贫血病人红细胞膜骨架蛋白的研究

A Study on the Erythrocyte Membrane Skeletin in Aplastic Anemia by Means of Using SDS-PAGE Method

十二烷基磺酸钠—聚丙烯酰胺凝胶电泳(简称为SDS-PAGE)方法分离12例再生障碍性贫血(简称再障)病人红细胞膜蛋白,发现其中有6例红细胞骨架蛋白带1、带2和带4有不同程度减少或缺损。同时用扫描电子显微镜观察其红细胞形态,发现亦有不同程度异常,表现为棘状、刺状及波浪状。提示红细胞骨架蛋白的含量与红细胞的形态有密切关系。

The erythrocyte membrane protein was studied by means of using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) method in 12 patients with aplastic anemia. The band1, band 2 and band 4 of the skeletin of the erythrocyte membrane protein in 6 cases decreased variously. Most of the erythrocyte varied in shape, thorny and wavy scanning electron microscopy. We have found that the content of the erythrocyte membrane protein skeletin is remarkably related to the shape and tha age of the erythrocyte signicantly.