凝胶材料配比对丁香罗勒油透皮凝胶体外透皮性能的影响

Effect of Gel Material Ratio on in vitro Percutaneous Absorption of Basil Oil Transdermal Gel

目的:探索凝胶材料配比对丁香罗勒油透皮凝胶体外透皮性能的影响。方法:以CMC-Na和PVA为辅料,制备丁香罗勒油透皮剂。采用改良Franz扩散池,以鼠背皮肤为屏障进行经皮渗透试验,以丁香酚含量为指标,通过气相色谱法检测丁香罗勒油的经皮渗透量。结果:CMC-Na和PVA总量对丁香罗勒油透皮能力有较大影响,以25%为最佳;CMC-Na和PVA的比例对丁香罗勒油透皮能力无影响,最佳比例4∶2。结论:丁香罗勒油透皮凝胶可极大地提高丁香罗勒油的药效。

Objective： To investigate effect of gel material ratio on in vitro percutaneous absorption of basil oil transdermal gel. Method： With CMC-Na and PVA as accessories to prepared basil oil transdermal gel. Modified Franz diffusion cell was used, percutaneous penetration test was isolated with mouse dorsal skin as barrier, with the content eugenol as index, percutaneous permeation quantity of basil oil was detected by gas chromatography. Result： Ratio of polyvinyl alcohol and sodium carboxymethyl cellulose showed no significant effect on transdermal ability of basil oil, test determined 2：4 was the best ratio; But their concentration in gel matrix had a certain influence on transdermal ability of basil oil, the content of them with 25% was optimal. Conclusion： These results suggested that basil oil transdermal gel could greatly improve efficacy of basil