泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响

Influence of Zexie Danming Drink on Serum Lipids and Adiponectin in Rats with Hyperlipidemia

目的:观察泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响。方法:以高脂饮食喂养14 d建立高脂血症大鼠模型。分别以泽泻丹明饮高剂量生药(4.0 g.kg-1)、中剂量(2.0 g.kg-1)、低剂量(1.0 g.kg-1)及血脂康(20 mg.kg-1)进行干预,共21 d。监测血清甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL)和脂联素(ADP)水平,并在光镜下观察大鼠肝脏病理变化。结果:泽泻丹明饮高剂量组与模型组比较,TC,TG显著降低(P<0.01),LDL-C明显降低(P<0.05),HDL-C有升高趋势,血清ADP水平显著升高(P<0.01)。中剂量组与模型组比较血清ADP水平明显升高。结论:泽泻丹明饮中、高剂量组可调节血脂、脂联素水平,具有良好的改善血脂紊乱作用。

Objective： To observe the influence of Zexie Danming Drink （ZDD） on serum lipids and adiponectin in hyperlipidemic rats. Method ： A high-fat diet was fed 14 d to establish rat model of hyperlipidemia. Rats in different groups were given drugs accordingly for 21 days： ZDD high dose （4.0 g ·kg^-1 ） , medium dose （2.0 g ·kg^-1）, low dose （1.0 g ·kg^-1） and Xuezhikang （20 mg ·kg^-1）. Serum triglycerides （TG）, cholesterol （TC）, high density lipoprotein cholesterol （HDL）, low-density lipoprotein cholesterol （LDL）, and adiponeetin factors （ADP） and liver pathological changes were determined and observed. Result： Compared with model group, TC and TG in ZDD high dose group were significantly lowered （P 〈 0.01 ） , LDL-C decreased significantly （P 〈 0.05） , serum ADP level increased significantly 1 （P 〈 0.01 ） and with a trend of elevation in HDL-C,. Compared with model group, in the middle dose group serum ADP levelwas significantly increased. Conclusion ： ZDD of high dose or medium dose can regulate blood lipids and adiponectin levels, with good improvement for dyslipidemia.