摘要
了解可切削生物活性玻璃陶瓷 (MBGC)的潜在致突变性。方法 采用微核试验。按照有关规定制备MBGC材料浸提液 ,将浸提液和阴性、阳性对照液分别注入各实验组小白鼠的静脉内 ,于第 2次注射后 6h取其骨髓涂片 ,双盲法观察骨髓嗜多染红细胞内的微核发生率。结果 MBGC浸提液的微核率分别为 (2 .4+ 1.7)‰和 (2 .2 + 1.3)‰ ,与阴性对照组生理盐水 (2 .6 + 0 .9)‰无显著性差异。结论 该材料未见潜在致突变性。
Objective To evaluate the mutagenicity of machinable bioactive glass ceramics (MBGC) by micronucleus test of bone marrow. Methods The samples of MBGC extraction, negative control and passive control groups were injected in to the vein of the white rats. 6 hours after the last injection, the sections of bone marrow were made and the micronucleus viewed. Results MBGC micronucleus rate were (2.4+1.7) and (2.2+ 1.3). There was no significant difference on the rate of the micronucleus between the MBGC and the negative control group(2.6+0.9). Conclusion There is no potential mutagenicity for MBGC.
