血管性痴呆与事件相关电位

Vascular Dementia and Event Related Potential

目的：探讨血管性痴呆的事件相关电位（Ｐ３００）特点，及Ｐ３００用于鉴别血管性痴呆和阿尔茨海默病的可能性。方法：选用听觉。ｏｄｄ ｂａｌｌ诱发范式对２４例血管性痴呆（ＶＤ）、２５例阿尔茨海默病（ＡＤ）和２２例正常老年人（ＮＣ）进行Ｐ３００测试。结果：ＶＤ的Ｐ３００特点为：靶Ｐ３潜伏期延长，靶Ｎ２潜伏期延长并与认知障碍程度密切相关。ＶＤ与ＡＤ相比，ＡＤ的靶Ｐ２及靶Ｐ３波幅明显下降。结论：靶Ｎ２潜伏期是ＶＤ的Ｐ３００研究中一项重要指标，靶Ｐ２、Ｐ３波幅在ＶＤ与ＡＤ的鉴别诊断中有一定意义。

Aim: To study the characteristic of event related potential (P300) in vascular dementia and to evaluate the role of P300 in the differential diagnosis of vascular dementia and Alzheimer's disease. Methods: Odd ball auditory evoked model was used to test the P300 of 24 patients with vascular dementia(VD), 25 patients with Alzheimer's dementia (AD) and 22 normal controls (NC). Results: The characteristic of P300 in VD shows the target P3 potential was prolonged. the target N2 potential was also prolonged and correlated with the extent of dementia. The target P2,P3 amplitudes in AD was greatly de- creased in compare with that in VD. Conclusion: The target N2 potential is a very important item in P300 of VD: the tests of the target P2,P3 amplitudes make sense in the differential diagnosis of VD and AD.