急性脑梗死患者的血清IL-6和TGF-β1的浓度变化及意义

The Serial Alteration of Interleukin-6 and Transforming Growth Factor-β Concentrations in Patients with Acute Cerebral Infarction and Its Significance

目的：观察急性脑梗死患者的血清ＩＬ－６和 ＴＧＦ－βｌ的浓度变化并探讨其意义。方法：采用酶联免疫法测定３５例急性脑梗死患者和３０例健康人的血清ＩＬ－６和ＴＧＦ－β１的浓度。结果：脑梗死组发病后ｄｌ、３和７的血清ＩＬ－６浓度显著高于对照组（Ｐ＜０·０００１），而ｄ１和ｄ３的血清ＴＧＦ－β１浓度显著低于对照组（Ｐ＜０．００１）。结论：血清ＩＬ－６和ＴＧＦ－β１浓度的动态变化反映了急性脑梗死患者的炎症和免疫状态。

Aim: To observe dynamically the serial concentrations of IL-6 and TGF-β1 in patients with acute cerebral infarc- tion (ACI) and its significance. Methods: The serial concentrations of interleukin-6 (IL-6) and transforming growth factorβ1 (TGF-β1) in 35 patients with ACI and 30 healthy control subjects were measured by ELISA method. Results: The serial con- centrations of IL-6 in patients with ACI significantly exceeded those detected in the healthy control subjects at day 1. day 3 and day 7. the serial concentrations of TGF-β1 in patients with ACI significantly decreased compared with those of the healthy control subjects at day 1 and day 3. Conclusion: The dymanic changes of the serial alteration of IL-6 and TGF-β1 concentra- tions may reflect the immunological and inflammatory status of the patients with acute cerebral infarction.