摘要
目的: 探讨血小板活化在A1zheimer病中的意义。方法:应用流式细胞术检测了24例AD和13例对照组人群的血小板膜糖蛋白(GMP)CD41、CD62p和CD63的阳性表达率。结果:AD患者血小板3种GMP的表达率均显著高于对照组(P<0.05),其差异具有统计学意义。结论:血小板活化可能与AD患者血浆中淀粉样前体蛋白(APP)和β-淀粉样肽(βA4)浓度增高有关,故血小板活化与AD的发病机制有关。
Aim: To compare baseline activation of unstimulated platelets in patients with Alzheimer's disease (AD) with that in control subjects. Methods: Flow cytometry (FCM) was used to measure the levels of CD4l (GP Ⅱb/ Ⅲ a, P2 ),CD63P (GMP- 140) and CD62 (GP53) in 24 patients with probable AD and 13 age-matched control subjects. Results: Platelets of patients with AD exhibit greater unstimulated activation than those of controls. The levels of three platelet membrane glycoproteins (GMPs) were significantly higher than those of controls (P<0.05). Conclusion: In light of evidence that platelets are princi- pal source of both amyloid precursor protein and β-amyloid peptide in human blood, it is possible that AD platelet activation may reflect or even contribute to the pathogenesis of the disease.
出处
《中国临床神经科学》
2000年第2期110-111,共2页
Chinese Journal of Clinical Neurosciences
关键词
ALZHEIMER病
血小板活化
膜糖蛋白
Alzheimer's disease platelet activation membrane glycoproteins flow cytometry