血小板活化在Alzheimer病中的意义

Significance of Platelet Activation in Alzheimer's Disease

目的： 探讨血小板活化在Ａ１ｚｈｅｉｍｅｒ病中的意义。方法：应用流式细胞术检测了２４例ＡＤ和１３例对照组人群的血小板膜糖蛋白（ＧＭＰ）ＣＤ４１、ＣＤ６２ｐ和ＣＤ６３的阳性表达率。结果：ＡＤ患者血小板３种ＧＭＰ的表达率均显著高于对照组（Ｐ＜０．０５），其差异具有统计学意义。结论：血小板活化可能与ＡＤ患者血浆中淀粉样前体蛋白（ＡＰＰ）和β－淀粉样肽（βＡ４）浓度增高有关，故血小板活化与ＡＤ的发病机制有关。

Aim: To compare baseline activation of unstimulated platelets in patients with Alzheimer's disease (AD) with that in control subjects. Methods: Flow cytometry (FCM) was used to measure the levels of CD4l (GP Ⅱｂ/ Ⅲ a, P2 ),CD63P (GMP- 140) and CD62 (GP53) in 24 patients with probable AD and 13 age-matched control subjects. Results: Platelets of patients with AD exhibit greater unstimulated activation than those of controls. The levels of three platelet membrane glycoproteins (GMPs) were significantly higher than those of controls (P<0.05). Conclusion: In light of evidence that platelets are princi- pal source of both amyloid precursor protein and β-amyloid peptide in human blood, it is possible that AD platelet activation may reflect or even contribute to the pathogenesis of the disease.