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胃癌淋巴细胞免疫功能与脂质过氧化损伤的关系 被引量:4

The relationship between lymphocyte immune function and lipid peroxidative injury in gastric cancer patients
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摘要 目的 通过对胃癌患者外周血T淋巴细胞亚群、自然杀伤 (naturalkiller,NK)细胞活性以及红细胞超氧化物歧化酶 (erythrocytesuperoxidedismutase,E SOD)、红细胞脂质过氧化产物丙二醛 (ery throcytemaiondialdehyde,E MDA)、血浆丙二醛 (plasmamalondialdehyde ,P MDA)等指标的检测 ,了解胃癌患者机体氧自由基反应对淋巴细胞免疫功能可能产生的影响。方法 随机选取 31例经病理检查确诊的胃癌患者 ,在入院当天外周静脉采血对上述指标进行检测 ,另取健康献血者 2 0例作为对照。结果 OKT3、OKT4、OKT4/OKT8以及NK细胞活性、E SOD、E SOD/E MDA比值分别较正常组降低 35 %、46 %、47%、6 4%、36 %、5 1%。而E MDA、P MDA、OKT8百分率分别升高 40 %、11%、2 5 %。结论胃癌患者机体自由基清除系统功能受损 ,氧自由基 (oxygenfreeradical,OFR)产生增多 ,导致OFR堆积引起生物膜和生物大分子的脂质过氧化损伤 ,是引起机体细胞免疫功能低下的重要原因。 Objective We measured the changes of T lymphocyte subsets、natural killer cell activity(NK)、erythrocyte superoxide dismutase (E SOD)、erythrocyte malondialdehyde (E MDA)、plasma malondialdehyde (P MDA) in gastric cancer patients to investigate the effect of oxygen free radical reaction on lymphocyte immune function.Methods Thirty one patients with pathology proved gatric cancer were enrolled and blood samples were drawn from peripheral vein and OKT3、OKT4、NK cell activity、E SOD、E MDA、P MDA were measured. Results were compared with 20 healthy controls.Results In gastric cancer patients, the percentage of OKT3、OKT4、the ratio of OKT4/OKT8 and NK cell activity、E SOD and the ratio of E SOD/E MDA,which represent tissue antioxidative activity decreased by 35%、46%、47%、64%、36%、 and 51% respectively, while compared with normal controls.The level of E MDA、P MDA and the percentage of OKT8 increased by 40%、11%、 and 25% respectively.Conclusion In gastric cancer patients,the function of organic oxygen free radical clearing system is impaired and the products of oxygen free radicals was increased,resulting in lipid peroxidative injury to the biological membrane and molecules, which may be the important cause of the reduction of cell immune function.
出处 《中华普通外科杂志》 CSCD 2000年第6期361-363,共3页 Chinese Journal of General Surgery
关键词 淋巴细胞 胃肿瘤 脂质过氧化物 免疫功能 Lymphocytes Stomach neoplasms Free radicals
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  • 1王长安,中国免疫学杂志,1988年,4卷,44页
  • 2吴裕Xin,上海免疫学杂志,1985年,5卷,156页

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