摘要
本文在研究超声造影剂 (UltrasoundContrastAgents ,以下简称UCA)单个包膜微泡的谐振与散射特性的基础上得到了具有一定尺寸分布的包膜UCA的线性散射特性 ,分析了UCA浓度与肺循环尺寸对散射特性的影响 ,描述了超声场加快UCA声学消失的现象。根据B超成像原理建立了UCA的散射特性与视频强度之间的关系。理论和实验研究表明 :造影散射与视频强度的动态变化是UCA浓度变化和包膜微泡自身不稳定性共同作用的结果 ,对强度 时间曲线进行校正 ,补偿微泡的不稳定性引起的冲洗期加速下降的影响后 。
This study was designed to investigate the linear scattering properties of encapsulated ultrasound contrast agents (UCA) with certain size distribution. The influence of the concentration of UCA and size distribution of lung capillary on scattering of UCA was analyzed, and the phenomenon of UCA bubble disappearing acoustically due to ultrasound signification was described. The mathematical relationship between the scattering of UCA and Bmode video intensity was set up on the basis of Bmode imaging principles. The results of this study demonstrated that the variation of video intensity was the combination contribution of the change in local UCA concentration and the instability of UCA bubbles. The timeintensity curve modified by UCA bubbles′instability might be used to evaluate tissue perfusion more exactly.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
2000年第2期131-137,159,共8页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金!(No.39570217)
西安交通大学研究生院博士学位论文基金资助
关键词
超声造影剂
包膜微气泡
强度-时间曲线
Ultrasound contrast agents
Encapsulated microbubble
Time-intensity curve
