微量液基稀释法测定化合物特苄康唑的体外抗真菌活性

In vitro antifungal activity study of terbiaminazole, a new triazole antifungal agent, by broth microdilution testing

参照美国国家临床试验标准化委员会 (NCCL S)提出的标准 ,以氟康唑、酮康唑和布替萘芬为对照 ,用微量液基稀释药敏试验方法 ,测定特苄康唑对 12种临床常见真菌的最低抑菌浓度 (MIC80 )。结果除烟曲霉外 ,特苄康唑对其他 11种真菌的 MIC80 均在 4mg/L以下 ,其体外抗真菌活性明显优于氟康唑 ,尤其对酵母的抗菌活性是氟康唑的 8～ 2 5 6倍 ,与酮康唑作用相当。结论 :特苄康唑在体外具有广谱、高效的抗真菌活性 ,有进一步研究的价值。

In the broth microdilution testing procedure proposed by the National Committee for Clinical Laboratory Standards (NCCLS), terbiaminazole, a new triazole antifungal agent, with MICs at which 80% of the strains tested are inhibited (MIC 80 s) under 4 mg/L, was more active than fluconazole against different fungi. These results demonstrated that ZJ522 has activity against fungi with broad spectrum and high potency, superior to that of its analogue fluconazole.