司帕沙星治疗非淋菌性尿道炎的临床疗效观察

Observation on clinical efficacy of sparfloxaicn in the treatment of nongonococcal urethritis

探讨司帕沙星治疗非淋菌性尿道炎 (NGU )的临床疗效以及比较不同疗程的司帕沙星对 NGU的治疗效果。将 87例 NGU患者随机分为三组 ;A组 :司帕沙星 0 .2 g qd,连续 7d;B组 :司帕沙星 0 .2 g qd,连续10 d;C组 :米诺环素 0 .1g bid,连续 7d。结果 :三组的临床痊愈率和总有效率分别是 79.41%、81.2 5 %、76 .19%和 94.12 %、93.75 %、90 .48% ;细菌清除率分别是 95 .12 %、97.37%和 92 .31% ;无论是临床疗效或细菌清除率三者之间均无明显统计学差异 (P>0 .0 5 )。司帕沙星治疗组不良反应发生率仅为 7.14% ,明显低于米诺环素治疗组的 36 .6 7% (P<0 .0 1)。结论 :应用司帕沙星 7d疗法治疗 NGU取得满意疗效。

Objective: to study the clinical efficacy of sparfloxacin with different therapeutic course in the treatment of nongonococcal urethritis. Methods: 87 cases of nongonococcal urethritis was randomly divided into three groups. A group was treated with sparfloxacin 0.2g qd for 7 days; B group was treated with sparfloxacin 0.2g qd for 10 days; C group was treated with minocycline 0.1g bid for 7 days. Results: the cure rates and overall effective rate of three groups were 79.41%, 81.25%, 76.19%, and 94.12%, 93.75%, 90.48%, respectively. The bacterial clearance rate was 95.12%, 97.37%, 92.31%, respectively. For the clinical efficacy or the bacterial clearance rate, there was no statistically significant difference in all groups ( P >0.05). The adverse reactions rate was only 7.14% in sparfloxacin group and lower than 36.67% of minocycline ( P <0.01). Conclusion: a 7 day regimen with sparfloxacin was found to be satisfactory for the treatment of nongonococcal urethritis.