南通市人群白喉免疫水平调查

Investigation on immune level of diphtheria among population in Nantong City

目的：为了解南通市人群白喉抗体水平，合理制定免疫接种计划提供科学依据。方法：采用锡克氏试验、间接微量血球凝集试验进行人群白喉免疫水平调查。结果：人群锡克氏试验阳性率14．15％，6岁以下儿童均在10％以下，10岁以上年龄组均在10％以上，20～40岁组在20％以上。人群白喉抗体阳性率54．28％。接种组与未接种组，全程接种组与本全程接种组之间均有显著差异。结论：在目前基本无白喉病例的情况下，人群对白喉的免疫力主要来源于人工免疫。目前在计划免疫工作中必须全程接种才能保证免疫效果，同时要注意成人的预防接种工作，提高整个人群的免疫水平。

Objective To investigate the immune level of diphtheria and to provide basis for vaccination strategy in Nantong city. Methods: Schick test and micro-indirect heamagglutination test were used. Results: The positive rates of Schick test in population was 14. 15% and the positive rate of children aged below 6, over 10 years old and adults aged 20~40 were≤10 %, ≥10 % and ≥20% respectively. The positive rate of antibody to diphtheria was 54. 28%. There was significant difference betwee groups of with and without vaccination. A significant difference was noticed between groups of whole course and non-whole course vaccination too. Conclusion:The immune level among population of diphtheria was decided by inoculation of vaccine in the condition that there was no clinical case almost now. Only whole course of vaccination can ensure the effectiveness of vaccination in EPI, meanwhile inoculation among the adult should be noticed to improve the immune level in population.[