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胆道闭锁肝纤维化无创性诊断的研究进展 被引量:1

Study on non-invasive diagnosis of biliary atresia hepatofibrosis
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摘要 胆道闭锁是儿童进行肝移植的最常见的胆源性肝脏疾病,进行性肝纤维化是本病的显著特点,即使进行了肝门空肠R—Y吻合术,大多数患儿术后仍不可避免的出现肝纤维化的进行性加重,直至发展成为肝硬化、肝衰竭,并出现一系列并发症。因此肝纤维化评估是胆道闭锁患儿术后随访的重要内容,准确了解肝纤维化程度,对胆道闭锁患儿的病情评估有着重要的意义。肝组织活检是判断肝纤维化分级的金标准,但是其本身存在许多问题。运用多项无创性指标对患儿肝纤维化程度进行评估成为目前胆道闭锁预后研究的热点,本文对主要应用于胆道闭锁患儿肝纤维化的若干无创性诊断进行系统性分析,并分别从影像学和血清学两个方面进行综述。 Biliary atresia (BA) is the most common biliary liver disease during liver transplantation for children. It is notably characterized by progressive hepatofibrosis. Even after Kasai operation, most children patients will unavoidably suffer progressive worsening of hepatofibrosis. Finally, they may be hit by cirrhosis, hypohepatia as well as a series of complication. Hepatofibrosis evaluation is known as a key component in the visit to child patients of BA after operation. Accurate understanding towards the degree of hepatofibrosis is of great significance for disease assessment of child patients. Hepatic tissue biopsy is carded out as a gold standard to grade hepatofibrosis. However, it still encounters many problems. Evaluation on hepatofibrosis of child patients based on multiple non-invasive indexes has attracted great attention in the study on biliary atresia prognosis at present. In this paper, the systematic analysis of some types of non-invasive diagnosis for hepatofibrosis of child patient is carried out. Furthermore, a summary is given in light of iconography and orrhology.
出处 《国际外科学杂志》 2012年第11期773-777,共5页 International Journal of Surgery
关键词 胆道闭锁 肝硬化 诊断 Biliary atresia Liver cirrhosis Diagnosis
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