双酚A对哺乳动物生殖系统影响的研究进展

The Research Advances of Bisphenol A Effects on Mammalian Reproductive Function

现代工业中,双酚A(BPA)被广泛应用于聚碳酸酯塑料和环氧树脂的制造,同时其也是一种具有雌激素样作用的化合物。因其被大量使用,已造成人等哺乳动物广泛暴露其中。动物实验结果表明:雌性妊娠期或动物新生期暴露于BPA可诱发后代或动物幼年的性早熟、乳腺组织发育异常、前列腺组织增生及雄性精子生成下降等,最终会导致乳腺组织的癌前病变及生殖道的严重损害。另外,对暴露BPA的人群调查也发现,BPA对生殖系统有明显的毒性作用,其中包括可导致男性性功能障碍等。

Bisphenol A（BPA） is widely used for the manufacturing of polycarbonate plastic and expoxide resins in the modem industrial world. Meanwhile,it has potential estrogenic properties. Due to its broad and sufficient usage in the daily life, mammal including humans is widely exposed to BPA, which is a potential risk of health lesion. The results from laboratory experiments showed that the offspring or newborn animals would have some kinds of diseases such as precocious puberty,the abnormality in breast tissue development,prostatic hyperplasia and decline in spermatogenesis if the pregnant animals or newborns were exposed to BPA, which finally lead to premalignant lesions of breast tissue and severe lesions of genital tract. Besides,the clinical investigation also showed that BPA had some obvious adverse effects on human reproductive system, such as male sexual dysfunctions.