精子氧化损伤及抗氧化剂的研究

The Seminal Oxidative Damage and Antioxidant

随着对男性生殖健康的关注,人们开展了许多关于精子氧化损伤和抗氧化剂在男性生殖系统中的应用研究。在正常的生理条件下,精子产生微量的活性氧(reactive oxygen species,ROS),这对于受精、顶体反应和获能是必需的。然而,如果产生的ROS增加超过自身清除能力的增加,就会导致精子质膜的过氧化损伤和DNA完整性的丢失,最终导致精子细胞死亡、降低受精率。目前,实验室和临床已经有许多研究关注抗氧化剂在氧化损伤引起的男性生殖问题中的作用,主要通过抑制ROS的产生或者消除过多的ROS来保护精子免受氧化损伤的影响,特别是在缺乏精浆的体外处理中尤为重要。

Many studies were focused on the effect of oxidative damage and antioxidants on male reproductive system. Sperm physiological produces small amounts of reactive oxygen species （ROS）, which is necessary for fertilisation, acrosome reaction and capacitation. However, if the increased production of ROS exceed the increased elimination, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. There were many studies concerning the roles of antioxidants in the oxidative damage caused by the male reproductive problem. Antioxidant mainly acts through inhibition of ROS production or elimination of the excessive ROS to protect sperm, especially in vitro treatment in the absence of seminal plasma.