肿瘤辐射敏感性与细胞凋亡

Tumor radiosensitivity and apoptosis

辐射敏感性是肿瘤细胞复杂的生物学现象 ,在辐射诱导的细胞反应中具有不同的组织细胞类型特异性。肿瘤辐射敏感性与辐射诱导的细胞凋亡密切相关 ,并受 p5 3及其相关蛋白、Bcl- 2基因家族蛋白、Fas及神经鞘磷脂 -神经酰胺介导的信号途径、caspases级联反应等调控。

Radiosensitivity is a complex phenomenon in tumor cells and there exist special biological effects in different types of tissues' cells in inadiation induced cell responses. Tumor radiosentivity is tightly connected with irradiation induced apoptosis and is regulated by many protein products of apoptosis related genes such as p53 and related proteins, Bcl 2 gene family proteins, Fas and sphingomyelin/ceramide mediated signalling pathways and caspases cascade etc.