放射抑制再狭窄的细胞及分子机制

Cellular and Molecular mechanisms of radiation for the inhibition of restenosis

放射抑制再狭窄的机制是多方面的。它既可诱导血管平滑肌细胞有丝分裂周期阻滞 ,抑制平滑肌细胞分裂及增殖 ,又可直接诱导平滑肌细胞凋亡 ,还可抑制单核 /巨噬细胞及各种生长因子 ,阻止再狭窄过程的起始因素。血管内放射导致细胞死亡的主要形式为凋亡 ,电离辐射预防再狭窄的主要机制是平滑肌细脑的增殖抑制。

The prevention of restenosis by radiation exists a lot of mecranisms, including smooth muscle cells (SMCs) division cycles arrests, inhibition of SMCs proliferation, SMCs apoptosis,inhibition of macrophage/monocyte and cytokines. Apoptosis is a major style of cell death induced by endovascular radiation. The inhibition of SMCs proliferation induced by radiation is a main mechanism for prevention of restenosis.