中西医结合治疗HP阳性慢性胃炎疗效观察

Efficacy of Integrative Medicine in the Treatment of HP-positive Chronic Gastritis

目的观察中药胃复春联合奥美拉唑、阿莫西林及克拉霉素标准三联疗法治疗幽门螺杆菌(Hp)阳性慢性胃炎的临床疗效及用药安全性。方法将100例Hp阳性的慢性胃炎患者随机分成两组,两组患者均先口服奥美拉唑、阿莫西林及克拉霉素治疗7 d,之后用奥美拉唑治疗35 d。治疗组加用胃复春,对照组不用。疗程结束后4周复查胃镜,行Hp检测并评价临床疗效。结果两组临床疗效比较,差异有统计学意义(P<0.01);两组Hp阴转率比较,差异有统计学意义(P<0.01)。结论胃复春联合奥美拉唑、阿莫西林及克拉霉素标准三联疗法治疗Hp阳性的慢性胃炎疗效显著,Hp阴转率较高,不良反应少,有较高的临床应用价值。

Objective： To observe the clinical efficacy and safety of drugs of weifuchun tablets plus the standard triple therapy of omeprazole, amoxicillin and clarithromycin in the treatment of Helicobacter pylori （Hp） -positive chronic gastritis. Methods： 100 patients with Hp positive chronic gastritis were randomly divided into two groups, both of whom were treated with omeprazole, amoxicillin and clarithromycin first for 7 d and then were treated with omeprazole for 35 d. The treatment group was treated again with Weifuchun. Four weeks after the treatment, endoscopy and Hp test were implemented and clinical efficacy was evaluated. Results： Comparing the clinical efficacy, the difference was statistically significant （P〈0.01）; comparing Hp seroconversion rate of the two groups, the difference was statistically significant （P〈0.01）. Conclusion： Weifuchun plus the standard triple therapy of omeprazole, amoxicillin and clarithromycin in the treatment of Hp-positive chronic gastritis has a significant effect with a high seroconversion rate and rarely clinical adverse reactions. It has a high clinical value.