降钙素原在关节置换术后感染中的作用

Value of procalcitonin in detection of infections after arthroplasty

目的探讨降钙素原在关节置换术后感染中的检测价值。为降低术后感染提供理论参考依据。方法选取2009年1月-2011年12月进行关节置换术并发生术后感染的24例患者为观察组,同期进行关节置换术未发生感染的24例患者为对照组,将两组患者的血清降钙素原、C反应蛋白及白介素6的阳性率及含量进行比较。结果观察组血清降钙素原、C反应蛋白及白介素6的阳性率分别为87.50%、95.83%、83.33%,含量分别为(8.97±0.56)μg/L、(9.12±0.43)mg/L、(134.56±11.84)pg/ml,均高于对照组,且深层感染患者高于浅层患者,差异均有统计学意义(P<0.05)。结论降钙素原在关节置换术后感染中的检测价值较高,可作为了解该类手术患者感染的指标之一。

OBJECTIVE To investigate the value of procalcitonin in detection of the infections after arthroplasty so as to provide theeorotinal basis for reducing the postoperatiue infections. METHODS A total of 24 patients with infections,who underwent arthroplasty from Jan 2009 to Dec 2011, were selected as the observation group, and another 24 patients without infections who underwent the arthroplasty were chosen at the same period as the control group. The positive rate and the content of the serum procalcitonin, C-reactive protein, and interleukin-6 were compared between the two groups. RESULTS The positive rates of the serum procalcitonin, C-reactive protein, and interleukin-6 of the observation group were 87. 50%, 95. 83%, 83.33%, respectively, and the contents of the observation group were（8.97 ± 0.56）μg/L, （9. 12±0.43） mg/L, and（134.56 ± 11.84） pg/ml, respectively, both the positive rate and the contents were higher in the observation group than in the control group,which were higher in the patients with deep infections than in the patients with superficial infections, the differences were all statistically significant （P〈0.05）. CONCLUSION The procalcitonin has significant value in the detection of infections after arthroplasty, it can be used as one of the indicators for the infections in the patients undergoing such surgery.