芜菁还阳参中倍半萜类成分的分离和鉴定

ISOLATION AND IDENTIFICATION OF SESQUITERPENES FROM CREPIS NAPIFERA

目的 对芜菁还阳参 (Crepisnapifera (Franch)Babc.)根的化学成分进行研究。 方法 采用溶剂分配及各种色谱方法进行分离纯化。得到 2个化合物 ,用1HNMR ,13 CNMR ,DEPT ,1H 1HCOSY ,HMQC ,HMBC ,ROESY ,MS和UV光谱技术进行鉴定。结果 得到 2个萜类化合物 ,分别是Δ4 ,9 二烯 重排桉烷 13,15 二羧酸 15 β D 葡糖苷 ,命名为还阳参酸苷 (napiferoside ,I)和蒲公英醋酸酯 (acetatetaraxasterol,II)。

AIM In order to obtain active compounds of the roots of Crepis napifera (Franch) Babc (Compositea), its chemical constituents were studied. METHODS Solvent partition and gel column chromatography, recrystalization and spectrum were used to extract, isolate and identity the constituents. RESULTS One sesquiterpene (I) and one triterpene (II) were obtained. (I) and (II) were elucidated as Δ 4,9 dien eudesmine 13,15 dicarboxylic acid 15 β D glucopyranoside (I) and acetate taraxasterol (II) respectively, based on 1HNMR , 13 CNMR , 1H 1H COSY, HMBC, ROESY, MS and IR spectroscopic data and literature data. CONCLUSION Compound I is a new eudesmane sesquiterpene glycoside named as napiferosied.