葡萄膜炎的免疫学治疗进展

Current immunologic therapy of uveitis

葡萄膜炎是中青年年龄组主要影响视力的疾病之一。葡萄膜炎分为前葡萄膜炎和后葡萄膜炎。近年来 ,对葡萄膜炎免疫过程包括T细胞激活、白细胞移行、效应器反应等的理解 ,促进了免疫特异治疗方法迅速发展。针对以上免疫过程 ,分别采用不同的免疫治疗 ,为葡萄膜炎的治疗开辟了一条崭新的道路。目前 ,抑制T细胞激活、针对细胞粘附分子、抑制效应器反应、诱导免疫耐受等方法已进入实验阶段 ,但应用于临床尚需进一步研究。以内源性后葡萄膜视网膜炎 (EPU)为例综述了葡萄膜炎免疫特异治疗的研究现状。

Uveitis ranks as one of the major causes of visual handicap in adults.It can be divided into anterior uveitis and posterior uveitis.Recently,with the immunological mechanism of uveitis being understood,specific immunotherapy is rapidly being developed and is now being tested in clinical trials.According to the immunological mechanism,different approaches to immunotherapy can be used including inhibiting T cell activation,targeting adhesion molecules,inhibiting effects or responses and inducing tolerance.This review to focus on current immunologic therapy of uveitis utilizing endogenous posterior uveoretinitis(EPU)as an example.