葡萄球菌和肠球菌耐药监测

Surveillance on Bacterial Resistance of 1779 Strains of Staphylococcus and Enterococcus

目的调查分析四川省人民医院1 779株葡萄球菌和肠球菌分布及其对常用抗菌药物的耐药性。方法采用VITEK全自动细菌鉴定仪及纸片扩散法(K-B法)进行鉴定及药物敏感性分析。结果金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)检出率占54.3%,未发现对万古霉素、替考拉宁和利奈唑胺的耐药株;肠球菌属中,屎肠球菌和粪肠球菌均已出现对利奈唑胺和替考拉宁耐药的菌株。结论四川省人民医院葡萄球菌和肠球菌中金黄色葡萄球菌对万古霉素、替考拉宁和利奈唑胺均敏感,但葡萄球菌和肠球菌耐药性需加强监测,并采取有效控制措施。

Objective To investigate the clinical pathogen resistance profile to antimicrobial agents of 1 779 stains of staphylococcus and enterococcus. Methods A total of 1 779 strains were identified with a Vitek -2 mcrobiology analyzer and antimierobial susceptibility testing was performed by Kirby - Bauer disk diffusion. Results Of the 1 779 clinical isolates, Methicillin resistant strains in Staphylococcus aureus （MRSA） accounted for 54.3%. None of Staphylococcus aureus isolates was found resistant to vancomycin, teicoplanin or linezolid. Among Enterococcus spp. , a few strains of E faeeium and E faecalis showed resistant to teicoplanin and linezolid. Conclusion Staphylococcus aureus were all sensitive to vancomycin, teicoplanin and linezolid. Surveillance of antimicrobial agents is in urgent demand and effective control measures are necessary.